Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Other Factors Influencing Hemoglobin Saturation  Temperature, H +, P CO2, and BPG  Modify the structure of hemoglobin and alter its affinity for oxygen  Increases of these factors:  Decrease hemoglobin's affinity for oxygen  Enhance oxygen unloading from the blood  Decreases act in the opposite manner  These parameters are all high in systemic capillaries where oxygen unloading is the goal
{}