Dose–response relationship of a-wave recoveries in Rlbp1-/- mice treated with scAAV8-pRLBP1(short)-hRLBP1. Data points represent a-wave recoveries of individual mouse eyes (1 eye per mouse) assessed 12 or 13 weeks postsubretinal delivery of 3 × 106, 3 × 107, 3 × 108, or 1 × 109 vg/eye of scAAV8-pRLBP1(short)-hRLBP1 or 1 × 109 vg/eye of a  vector. The 95% confidence interval (CI) of the mean from several cohorts of Rlbp1+/+ mice is represented by the shaded region (n = 23 eyes). Calculations of p-values compare treated eyes to naive Rlbp1-/- eyes. ***P ≤ 0.001; ****P ≤ 0.0001.
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