Binded EE (GLM 50 mg) n=41 PBO CO to GLM 50 mg + MTX Binded EE (MTX at BL dose) n=36 GLM may be increase to 100 mg after DBL n=29 MTX may be added after DBL n=40 Binded EE (no change) Binded EE (GLM 100 mg) n=15 GLM may be increased to 100 mg after DBL n=20 SC injection Week 0 and q4Wks Week 16*: Early Escape (EE) Week 24: Placebo CO Week 52: LTE** Week 268 Group 1 Placebo + MTX n=133 Group 2 GLM 100 mg + Placebo n=133 Group 3 GLM 50 mg + MTX n=20 Group 4 GLM 100 mg + MTX n=89 *At Week 16, any patient with <20% improvement from BL in both SJC and TJC had to enter EE in a double-blinded fashion **Dose escalation at the discretion of the PI was allowed after Week-52 DBL and unblinding Patients with active RA despite MTX therapy (n=444)After presmedic.com jordan@presmedic.com (917) 856-0582
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