), and digested with EcoR1 and analyzed by Southern blotting by using a IgH probe. The band of 6 kb corresponds to the germ line (GL) IgH locus. IgH rearrangements corresponding to clonal expansions are indicated with an arrowhead. Wild-type, TRAF2DN, and TRAF2DN/Bcl-2 mice either asymptomatic (premalignant) or with overt lymphoma (disease) were analyzed. The ages in months of the mice (identified by number) analyzed were 17 (102), 15 (137), 14 (158, 157, and 148), 13 (83 and 316), and 12 (302, 327, 87, 89, and 95).
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