Natural history of HPV infection and cancer as shown at top.  The bottom graph shows the correlation of the stages during the natural history with age. As shown in the graph, the age of peak high-grade intraepithelial lesion (HSIL) or precancer occurs 5 to 10 years after HPV infection.<div>Source: Schiffman M, Solomon D. Clinical practice. Cervical-cancer screening with human papillomavirus and cytologic cotesting. N Engl J Med. 2013;369:2324-31.
{}