Roles of cyclin-dependent kinases
{"Image DocumentName": "Roles of cyclin-dependent kinases", "Image ImageDescription": "Roles of cyclin-dependent kinases. (a) Cyclin-dependent kinases (CDKs) catalytic subunits and cyclins responsible for progression through the indicated cell-cycle phase. Arrowheads indicate activation, and flat bars indicate inhibition by the specific endogenous negative regulator. (b) Transcription-related CDKs promote elongation of nascent transcripts by phosphorylating the carboxy-terminal domain (CTD) of RNA polymerase II. (c) CDK5/p25 facilitates secretion of insulin by phosphorylating an as-yet incompletely defined set of substrates, possibly including munc 18, synapsin-1, and syntaxin, all of which are responsible for secretory vesicle alignment with, for example, the cytoskeleton and membrane (described in detail in [17]).", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}