Skewed X Chromosome Inactivation
{"Image DocumentName": "Skewed X Chromosome Inactivation", "Image ImageDescription": "X-linked disorders are generally rare in females and are usually attributable to advantageous silencing of the X chromosome that carries the mutant allele. Initial X-inactivation choice is presumed to be random. During proliferation, cells that have chosen the mutant X chromosome to be active can have a significant or total selective growth disadvantage - underrepresented in the adult carrier (negative cell selection). Postinactivation cell selection has been documented in carriers for a number of X-linked diseases e.g. Aarskog-Scott syndrome, X linked SCID. In contrast, the positive growth advantage of cells in which the mutant X is primarily active has been reported in a few conditions.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}