Adult lung mesenchymal cells are specifically targeted by Tbx4 lung enhancer. (A) Inducible transgenic expression (Cre or dnTβRII) in adult lung mesenchymal cells is controlled by a Tbx4 lung enhancer driven Tet-On system, shown by a schematic diagram. Expression of LacZ can be used as a marker for cells with active Tbx4 lung enhancer independent of Dox induction.  A novel profibrotic mechanism mediated by TGF-β-stimulated collagen prolyl hydroxylase expression in fibrotic lung mesenchymal cells.  Shi et al 2015.
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