Reading Frames Since nucleotide sequences are read three bases at a time, there are three possible frames in which a given nucleotide sequence can be read (in the forward direction) Since nucleotide sequences are read three bases at a time, there are three possible frames in which a given nucleotide sequence can be read (in the forward direction) Taking the complement of the sequence and reading in the reverse direction gives three more reading frames Taking the complement of the sequence and reading in the reverse direction gives three more reading frames
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