samples Parkinsonian Midbrain Human Normal Midbrain
{"Image DocumentName": "samples Parkinsonian Midbrain Human Normal Midbrain", "Image ImageDescription": "Our studies begin from here: from these autoptic pieces , as we say using the lab slang. On the right we see the human normal midbrain , where the subtantia nigra appears dark-pigmented, from neuromelanin-containing dopaminergic neurons and on the left we have a characteristic parkinsonian midbrain,whose the gross anatomical change is atrophy with nigrostriatal degeneration and an apparently suppressed neuromelanogenesis resulting as a bleching of the substantia nigra.due to the disappearence of dopaminergic neurons.The onset of motor dysfunction in PD is associated with a dramatic depletion in brain dopamine. Although histological abnormalities can be found in other dopaminergic and even non-dopaminergic cell groups, the most important site of changes is the origin of the dopaminergic nigrostriatal tract, the substantia nigra pars compacta, thus over the past years, the role of dopamine (DA) metabolism has been focus of neurodegeneration studies in PD. ). Post-mortem studies have consistently implicated oxidative damage in PD pathogenesis (2). The primary cause of oxidative stress, an imbalance between the production of reactive oxygen species (ROS) and the capacity of the cell to scavenge these toxic metabolites via its own antioxidant defence machine, has not been clear, but the leading candidate is the metabolism of dopamine itself, since it gives rise to various toxic species. Parkinsonian Midbrain. Human Normal Midbrain.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}