Histologic changes of extrinsic Aging
{"Image DocumentName": "Histologic changes of extrinsic Aging", "Image ImageDescription": "Clinical features of photoaged skin. Wrinkles. Furrows. Dryness. Loss of elasticity. Dyspigmentation. Histologic features of aged skin. Reduced numbers of fibroblasts. Reduced amount of extracellular matrix (ECM) Abnormal organization of ECM. Atrophy of subcutis. Most of us are well versed in both the clinical and histological features of aged skin listed here. Typically, the description of aged skin assumes that environmental contributions have caused insult overtime. Without additional insults insults that disrupt the cellular repair capacity, many of these features never become not present. Rather, in isolated chronologic aging, more frequently there is loss of subcutaneous fat, mild thinning of the epidermis, and scant alteration in elastic tissue. It is when additional environmental factors are superimposed, that change cellular function specifically as it relates to the balance in synthesis and degradation of dermal tissue, that we witness what we call aged skin. So, beyond each of these features is a mechanism of action\u2026a molecular pathway that is driven away from homeostasis.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}