Summary of phenotypic and genetic effects of duplications Novel phenotypes may occur because of increased gene copy number or because of altered expression in new chromosomal environment Homozygosity or heterozygosity for a duplication can be lethal or harmful Depends on size of duplication and affected genes Unequal crossing-over between duplicated regions on homologous chromosomes can result in increased and decreased copy number Copyright © The McGraw-Hill Companies, Inc.
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