Effects of pituitary adenylate cyclase-activating peptide (PACAP) on pacemaker currents recorded in cultured interstitial cells of Cajal (ICC) from mouse colon. (A) shows the pacemaker currents of ICC exposed to PACAP (1 nM) in voltage-clamp mode at -70 mV holding potentials. PACAP inhibited the amplitude and frequency of pacemaker currents in ICC. The dotted lines indicate the control resting current levels. Responses to PACAP are summarized in (B) and (C). Bars represent the means±SE. *Asterisks indicate a statistically significant difference from controls (p<0.05).
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