HA turnover Eukaryotic hyaluronidase (HYAL) gene family –3p21.3 –HYAL1, 2 and 3 Turnover of hyaluronan in most tissues is rapid –t 1/2 of ~1 day in epidermal tissues Large hyaluronan molecules in the extracellular space interact with cell surface receptors –Fragments produced by an associated GPI anchored hyaluronidase, most likely Hyal2.
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