Comparative orientations of UDG bound to p56, DNA, and ugi, with detailed views of the UDG-binding pocket containing both substrate and inhibitor elements on a UDG surface. UDG residues are shown with blue carbon atoms as is the surface, whereas substrate and inhibitor residues are shown with yellow carbon atoms. The second dimer of p56 is shown in green. ( A ) The p56 inhibitory helix bound to the HHV-1 UDG. Only the interacting side chains of the inhibitory helix and Glu26 of p56 are shown alongside UDG interacting residues. ( B ) Backbone of the uracil-containing strand of DNA bound to human UDG (PDB: 1SSP). ( C ) Residues of the ugi inhibitory strand bound to human UDG (PDB: 1UGH).
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