Methods: Data Parent study: Rakai Community Cohort Study (RCCS)  50 communities organized in 11 study regions (clusters)  All consenting adults aged 15-49 years  Annual surveys and biological samples Data from 3 rounds of RCCS – Used for in the CRT  Baseline (16 months: Feb 2005–Jun 2006)  Follow-up 1 (19 months: Aug 2006–Apr 2008)  Follow-up 2 (18 months: Jun 2008–Nov 2009) Trail registered with ClinicalTrials.gov- NCT02050763
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