HIV-1 Envelope glycoprotein structures Shown on the left is the structure of the HIV-1 Envelope membrane glycoprotein without a binding partner. On the right, the Envelope protein is shown interacting with three copies of the A12 protein, a small domain antibody. The top row shows the structures derived by cryo-EM, and on the bottom these same structures are fitted with subunit structures from X-ray crystallography. Adapted from Meyerson et. al. 2013 Proc Natl Acad Sci USA.
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