27 EPA for Bipolar Depression Two parallel studies of efficacy and biology Efficacy † 12 week double-blind RCT (n=51) Augmentation with EPA (1-2 gms) or Placebo **EPA superior to Placebo on HAM- D and CGI (p=0.04) Biology ‡ MRS before and after 12 weeks of EPA or Placebo augmentation (n=18 females) **Higher levels of N-acetyl aspartate (NAA) with EPA vs.
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