Tau Dysfunction And The Pathogenesis Of AD And Related Neurodegenerative Tauopathies Genetic Factors Tau Mutations APP, PS1, PS2 Mutations Environmental Factors Perturbation of 4R/3R Ratio Loss of Tau Function Gain of Toxic Function Hyperphosphorylation DeP-Tau Kinases Phophotases P-Tau Tau Dysfunction Tau Aggregation/ MT Loss Impaired Transport & Neurodegeneration .
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