Interferon-β1b (IFN-β1b) therapy corrects aberrant levels of TROVE2 , SSB , poly (A) + Y1 RNA, and poly(A) + U1 snRNA in RRMS. Blood samples were collected in PaxGene tubes from CTRL (N = 12), RRMS subjects not on IFN-β1b (RRMS - IFN-β1b, N = 12), and RRMS subjects on stable IFN-β1b therapy (RRMS + IFN-β1b, N = 4). Oligo dT was used for cDNA synthesis. Transcript levels of TROVE2 and SSB ( A ) or poly(A) + Y1 RNA and poly(A) + U1 RNA ( B ) were determined by quantitative PCR and normalized to CTRL = 1 after normalization to levels of GAPDH . Error bars are ± S.D. * P
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