Klentaq fragment Thumb Palm 3-5 exonuclease-like domain Fingers PDB: 3KTQ
{"Image DocumentName": "3\u2019-5\u2019 exonuclease-like domain", "Image ImageDescription": "Klentaq fragment. Thumb. Palm. 3\u2019-5\u2019 exonuclease-like domain. Fingers. The X-ray crystal structures of these polymerases resemble in overall morphology a cupped human right hand, with fingers (which bind an incoming nucleotide and interact with the single-stranded template), palm (which harbors the catalytic amino acid residues and also binds an incoming dNTP) and thumb (which binds double-stranded DNA) subdomains. Estos tres sub-dominios: pulgar, dedos y palma, forman el dominio con actividad polimerasa. En posici\u00f3n 5\u2019 respecto a este dominio, encontramos un dominio hom\u00f3logo al dominio 3\u2019-5\u2019 exonucleasa de E.coli, aunque en Taq carece de actividad catal\u00edtica. Finalmente, en la porci\u00f3n m\u00e1s 5\u2019 del fragmento Klenow, encontramos una regi\u00f3n que se encarga de unir el fragmento klenow al domino N-terminal de actividad exonucleasa 5\u2019-3\u2019 (el cual NO aparece en la imagen). PDB: 3KTQ.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}