Summary of Anti-VEGF Proposed Mechanisms of Action Based on Preclinical Models
{"Image DocumentName": "Summary of Anti-VEGF Proposed Mechanisms of Action Based on Preclinical Models", "Image ImageDescription": "1. May regress existing microvasculature1,2. KEY POINT: Based on preclinical models, anti-VEGF agents are thought to have a triple MOA that includes regression of existing microvasculature, normalization of surviving vasculature, and inhibition of vessel regrowth and neovascularization. 2. May normalize surviving mature vasculature3-5. Mandatory Slide. ADDITIONAL INFORMATION. This is a graphic representation and summary of the triple mechanism of action (MOA) of anti-VEGF agents, along with the consequences of their actions. May regress existing microvasculature1,2. Direct and rapid changes include a significant reduction in microvascular density, as seen in preclinical models1-3. May normalize surviving mature vasculature3-5. Reversal of structural and functional abnormalities may improve the vasculature\u2019s capacity for drug delivery, as seen in preclinical models3-5. May inhibit vessel regrowth and neovascularization2,3,6. Genentech is pursuing research to expand the understanding of the MOA of bevacizumab and other monoclonal antibodies that bind to VEGF. REFERENCES. Lee et al. Cancer Res. 2000;60:5565\u20135570. Inai et al. Am J Pathol. 2004;165:35\u201352. Gerber et al. Cancer Res. 2005;65:671\u2013680. Jain. Science. 2005;307:58\u201362. Tong et al. Cancer Res. 2004;64:3731\u20133736. Hicklin et al. J Clin Oncol. 2005;23:1011\u2013 May inhibit vessel regrowth and neovascularization2,3,6. 1. Lee et al. Cancer Res. 2000;60:5565\u20135570; 2. Inai et al. Am J Pathol. 2004;165:35\u201352; 3. Gerber et al. Cancer Res. 2005;65:671\u2013680; 4. Jain Science. 2005;307:58\u201362; 5. Tong et al. Cancer Res. 2004;64:3731\u20133736; 6. Hicklin et al. J Clin Oncol. 2005;23:1011\u20131027.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}