Serum concentration (mg/L)
{"Image DocumentName": "Serum concentration (mg/L)", "Image ImageDescription": "AUGMENTIN SR provides greater T>MIC than equivalent immediate release. 30. Amoxicillin 875 mg b.i.d. (all immediate release) 25. Amoxicillin 2000 mg b.i.d. (all immediate release) 20. AUGMENTIN SR 2000/125 mg b.i.d. (1125 mg immediate release mg sustained release amoxicillin) Serum concentration (mg/L) 15. PK/PD: Sustained-release technology enhances PK vs. conventional dosing. Only the novel sustained-release technology of AUGMENTIN SR allows the increase in T>MIC, leading to increased bacterial eradication. An increase in immediate-release amoxicillin to 2000 mg increases the initial serum concentration, but does not extend the bacterial killing time sufficiently to ensure maximal bacterial killing of resistant strains. It is the novel sustained-release design of AUGMENTIN SR that extends the time of therapeutic activity for amoxicillin to cover these strains mg/L. 35% 49% 26% Time (h) 1Kaye CM, Allen A, Perry S, et al. Clin Ther 2001; 23: 578\u2013584.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}