cbio course, spring 2005, Hebrew University Motivation (2) We need a rigorous way to decide on a threshold s* so that for s > s*, we call the sequences related Note: s* should obviously be s*(n,m) where n and m are the length of the 2 sequences aligned When we try matching sequence x against a D.B of N (N>>1) sequences, we need to account for the fact we might see high scores just by chance We can make 2 kinds of mistakes in our calls: FP FN → We want our rigorous way to control FP FN mistakes
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