CEACHRUCNRSCPUINRAINRIAINSERMINSTITUT PASTEURIRD ARIISEFSINERISINSTITUT CURIEINSTITUT MINES-TELECOMUNICANCERIRBAIRSNCIRADFONDATION MERIEUX Proof of concept for molecularly guided therapy: prospective trial for the future 10 Need to demonstrate that sequencing tumours (Exome-Whole GS) is of interest for treatment decision A national cooperative randomized study in early metastatic patient in some tumour types Comparing therapeutic decision based on NGS to current diagnostic procedures including defined genetic tests To be performed in the CLIP 2 (INCa- Fondation ARC- Unicancer) With the help of Pharmas to provide drugs already in phase 2 trials
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