Unfavorable Prognostic Factors High MRI lesion burden at first episode High MRI lesion burden at first episode Moderate-to-severe disability at 5 years Moderate-to-severe disability at 5 years Progressive clinical course from onset Progressive clinical course from onset Male gender Male gender Late onset (age >40 years) Late onset (age >40 years) Two or more relapses in first year Two or more relapses in first year
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