Sites of action of antidiabetic agents
{"Image DocumentName": "Sites of action of antidiabetic agents", "Image ImageDescription": "Carbohydrate. Stomach. \uf061-glucosidase inhibitors. Gut. I. Sulphonylureas and. meglitinides. Glucose. G. I. Adipose tissue. I. G. Insulin. G. G. I. G. TZDs. Pancreas. I. G. I. G. I. Different antidiabetic agents target distinct sites as part of their primary mechanism of action in reducing hyperglycaemia. Sulphonylureas (e.g. glyburide) and meglitinides (e.g. repaglinide) stimulate insulin release from the pancreas. Biguanides (e.g. metformin) mainly suppress hepatic glucose output. \uf061-glucosidase inhibitors (e.g. acarbose) delay digestion and absorption of carbohydrates in the gastrointestinal tract. TZDs (e.g. rosiglitazone) decrease IR in adipose tissue, skeletal muscle and liver. In addition, these agents may have a beneficial effect on \u03b2-cell function. Kobayashi M. Diabetes Obes Metab 1999; 1 (Suppl 1): S32\u201340. G. G. I. G. I. I. G. Muscle. G. Liver. TZDs. Biguanides. Adapted from Kobayashi M. Diabetes Obes Metab 1999; 1 (Suppl 1): S32\u201340.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}