Mechanism of Negative Pressure Pulmonary Edema The patient continues trying to inhale against the obstruction 2 An upper airway obstruction occurs 1 A high degree of negative intra- thoracic pressure develops 3 Venous return to the heart increases 4 Cardiac output decreases 5 Pressure in the pulmonary capillary bed increases 6 A disruption in the alveolar membrane junction occurs 7 Fluid from the interstitial space floods into the alveoli 8 Airway obstruction is relieved 9 Pulmonary edema remains 10
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