GVH Model - Response Donor T Cells recognize polymorphisms at the MHC of the host (non-self) They respond, proliferating and differentiating into effector cells Effector cells attack the host they recognize as non-self Effector cells attack the host they recognize as non-self Leads to graft versus host disease, resulting in organ damage, death Leads to graft versus host disease, resulting in organ damage, death Similar thing can happen during bone marrow transplant Similar thing can happen during bone marrow transplant T Cell
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