| haemoglobin and O2 transport
{"Image DocumentName": "| haemoglobin and O2 transport", "Image ImageDescription": "Contents page The erythrocyte: an overview Erythropoiesis The red cell structure Cell membrane DNA synthesis Red cell metabolism Haemoglobin and O2 transport. | haemoglobin and O2 transport A key function of a red cell is to carry and deliver oxygen to the tissues and return CO2 from the tissues to the lungs. As a result the red cell has developed a specialised molecule called haemoglobin (Hb). It is important to gain a basic understanding of its synthesis, functioning and metabolism as errors in these processes lead to a number of anaemic states. It\u2019s waste products are also released when a red cell is destroyed prematurely and are therefore a valuable indicator of haemolysis. A molecule called 2,3 \u2013 Diphosphoglycerate (2,3-DPG) sits between the \uf062 chains and when increased helps to offload oxygen to the tissues. Oxygen (O2) 2,3-DPG. GLOBIN CHAIN. A normal adult haemoglobin (Hb A) molecule consists of. 4 polypeptide (globin) chains: \uf0611\uf0612 \uf0621\uf0622. For more information on foetal haemoglobin click here. oxyhaemoglobin. deoxyhaemoglobin. HAEM MOLECULE. Each individual globin combines with one haem molecule. This molecule contains iron and binds oxygen in a reversible manner. A mature red cell (an erythrocyte) contains approximately 640 million haemoglobin molecules. Haemoglobinopathies. Thalassaemia: reduced rate of synthesis of either \uf061 or \uf062 globin chains. Within this group of inherited conditions there may be both ineffective erythropoiesis and haemolysis resulting in a microcytic anaemia sometime also with hypochromia. Sickle cell disease: an inheritance of two abnormal \uf062-globin genes (HbSS). The abnormality consists of a point mutation in the \uf062 globin gene. This results in Hb insolubility in it\u2019s deoxygenated state with crystallization within the red cell causing sickling of the cell and vascular occlusion. A common problem that affects primarily the Afro-Caribbean populations. Key point!", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}