Johnny Depp missed out on several major movie roles, some of which are classics.  Depp could have played Ferris Bueller in &#39;Ferris Bueller&#39;s Day Off&#39; &#40;part went to Matthew Broderick&#41;,  Jack Dawson in &#39;Titanic&#39; &#40;part went to Leonardo DiCaprio&#41;, John Smith in &#39;Mr. and Mrs. Smith&#39; &#40;part went to Brad Pitt&#41; and Neo in &#39;The Matrix&#39; &#40;part went to Keanu Reeves&#41;.  Pictured: Johnny Depp &#40;center&#41; in 2009 during the premiere of &#39;Public Enemies.&#39;  Brad Pitt &#40;bottom left&#41; appears in a scene from &#39;Mr. and Mrs. Smith.&#39;  Keanu Reeves &#40;upper left&#41; appears in a scene from &#39;The Matrix.&#39;  Matthew Broderick &#40;bottom right&#41; appears in a scene from &#39;Ferris Bueller&#39;s Day Off.&#39;  Leonardo DiCaprio &#40;upper right&#41; appears in a scene from &#39;Titanic.&#39; <span class=meta>(flickr.com&#47;photos&#47;nicogenin  |  Regency Enterprises  |  Warner Bros. Pictures  |  Paramount Pictures  |  Twentieth Century Fox Film Corporation)</span>
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