Prentice Hall c2002Chapter 555 Regulation of glycolysis by PFK-1 When the ratio [PEP]/[ADP] is high, flux through glycolysis decreases at the PFK-1 step When the ratio of [PEP]/[ADP] is low, PFK-1 is activated and glycolysis produces more ATP from ADP Thus the concentrations of PEP and ADP act allosterically through PFK-1 to regulate the activity of the entire pathway
{}