LOOP DIURETICS MECHANISM OF ACTION Excrete 15 - 20% of filtered Na + Elimination of K +, Ca + and Mg ++ Resistance of afferent arterioles - Cortical f
{"Image DocumentName": "LOOP DIURETICS MECHANISM OF ACTION", "Image ImageDescription": "Excrete % of filtered Na+ Elimination of K+, Ca+ and Mg++ Resistance of afferent arterioles. - Cortical flow and GFR. - Release renal PGs. - NSAIDs may antagonize diuresis. Treatment of heart failure. Diuretics Mechanism of action of loop diuretics. Loop diuretics are the strongest, prompting the excretion of 15-20% of the filtered Na+. They act in the thick segment of the ascending loop of Henle, inhibiting the cotransport of Cl--Na+-K+ at the luminal surface. They also increase the elimination of K+, as the increase in Na that reaches the distal convoluted tubule stimulates its exchange for K+ and H+; in addition, they also stimulate the secretion of renin and the production of aldosterone which augments the elimination of K+. By inhibiting carbonic anhydrase, they increase the urinary elimination of HCO-3. They also increase elimination of Ca++ and Mg++. GFR: glomerular filtration rate; PGS: prostaglandins; NSAIDs: nonsteroidal anti-inflammatory drugs.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}