Conditions That Limit Applicability Features That Should Be Extracted Into Evidence Tables Narrow eligibility criteria, high exclusion rate, low enrollment Eligibility criteria, proportion of screened individuals enrolled Differences between patients in study and the community Demographics (range and mean): age, gender, race, ethnicity Narrow or unrepresentative severity or stage of illness Severity or stage of illness (referral or primary care population) Run-in periods with high exclusion rates Run-in period: attrition rate before randomization and reasons (e.g., nonadherence, adverse drug events, no response) Events rates markedly different than in community Event rates in treatment and control groups Disease prevalence in study population different than community Prevalence of disease (for diagnostic studies) Population and Applicability
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