Hemostatic Plug Formation
{"Image DocumentName": "Hemostatic Plug Formation", "Image ImageDescription": "PRIMARY. AGGREGATION. Platelet Aggregation. Clotting. Hemostatic. Clot. Fibrin. SECONDARY. COAGULATION. Thrombin. Hemostasis: the termination of bleeding by mechanical or chemical means or by the complex coagulation process of the body, involving vasoconstriction, platelet aggregation, and thrombin and fibrin synthesis1. Primary hemostasis is the process of platelet-plug formation at sites of injury. It occurs within seconds of injury and is of prime importance in stopping blood loss.2. Secondary hemostasis describes the reactions of the plasma coagulation system to vascular injury that results in fibrin formation. It takes several minutes before this process is completed. The fibrin strands strengthen the primary hemostatic plug. This reaction is particularly important in larger vessels to prevent recurrent bleeding hours or days after the initial injury.2. Although presented here as separate events, primary and secondary hemostasis are closely linked. For example, activated platelets accelerate plasma coagulation, and products of the plasma coagulation reaction, such as thrombin, stimulate platelet aggregation.2. 0 min. 5 min. 10 min. Adapted from Ferguson JJ, et al. Antiplatelet Therapy in Clinical Practice. 2000: References. 1 Mosby\u2019s Pocket Dictionary of Medicine, Nursing and Allied Health. 5th ed. St. Louis, MO: Mosby-Year Book Inc;1998: Ferguson JJ. The physiology of normal platelet function. In: Ferguson JJ, Chronos N, Harrington RA; Antiplatelet Therapy in Clinical Practice. London: Martin Dunitz; 2000:15-35.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}