IT Baclofen for Spasticity Large % of refractory spasticity patients Intrathecal baclofen (ITB) has been used to treat spasticity since 1988, particularly dystonia secondary to cerebral palsy or traumatic brain injury ITB is an approved use of the Medtronic Infusion System The site of action is thought to be at the anterior horn cell It would be expected that intrathecal infusion would have good access to this site Motor Cortex Spinal Cord Medulla Anterior Horn
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