PE4, PE5, PE6, PE8, PE12 and PE21 slow down an age-dependent rise in the frequency of spontaneous point mutations in the rib2 and rib3 loci of mitochondrial DNA (mtDNA) in chronologically aging yeast grown under non-CR conditions. PE12 and PE21, but not PE4, PE5, PE6 or PE8, have similar effects on the frequency of spontaneous point mutations in the CAN1 gene of nuclear DNA (nDNA).
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