B-cell differentiation Memory B IgD+ IgM + Pro-B T T T T T T T T Centroblasts Memory B IgG+, IgA+ Plasma- cell Naive B T indépendent Marginal zone Transitional Immature B Pre-B T dépendent Bone marrow Secondary lymphoid organs (lymph nodes …) Germinal centre centrocytes Ab Blood Bone marrow Blood
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