Wife: Catherine de Medici Catherine de Medici, daughter in last Florentine Medici dynasty (Lorenzo II)  Overshadowed by Diane de Poitiers, longtime confidante and counsellor, as well as mistress, to Henry  Important because she was mother and regent to three kings  Her uncle, Pope Clement VII, refused Henry VIII's request for annulment; he arranged her marriage because he wanted an alliance with Francis against Charles V
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