Approaches to temporo-spatial optimization of IMRT (1) Planning with optimal margins (Internal Target Volume) (2) Planning with Motion kernel (a)Uniform approach (motion PDF) (b)Adaptive approach (sum influence matrix) (3) Gating / Unoptimized tracking – plans optimized separately, 1 best plan chosen out of several or all delivered dynamically (4) Optimized tracking – several plans optimized simultaneously, delivered dynamically A Trofimov et al PMB 50:2779 (2005)
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