5 Alpha Reductase Inhibitors Finasteride and Dutasteride Selective, competitive inhibitor of type II 5 alpha reductase, resulting in reduced prostatic levels of dihydrotestosterone, with reduction in prostate size and reduction of benign prostatic obstructio.n Finasteride - Improved urodynamic parameters of obstruction in placebo controlled trial using urodyamic assessment 8.1 cm reduction detrusor pressure at max flow 1.1 ml/sec improvement in max flow rate 22.8% reduction in prostate volume Improvement greater in prostates > 40 gm Abrams et al J Urol 1999; 161: 1513 Finasteride problem is cost - $120 per month unless repat entitled.
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