CHARM-Alternative Permanent study drug discontinuations 4.2 12.0 1.0 0.5 9.1 23.1 13.6 0.3 According to prior ACE-I intolerance Percent of patients 0 5 10 15 20 25 Hypo- tension Increased creatinine Cough Placebo Candesartan Increased potassium 0 2.6 (1/39) Angioedema Atacand® (candesartan) is approved in Australia for the treatment of hypertension at a maximum approved dosage of 16mg once daily.
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