(A) Photomicrographs in a higher original objective (x40) of the different groups (SHAM, OVX, and RLX) and periods (14 and 42 days), in which is possible to observe an increased area of diaminobenzidine-stained cells (brown areas) around the peri-implant bone where the biomarker RUNX-2 were intense, represented by black arrow, denoting a greater active of the osteoblastogenesis; (B) The chart shows the scores submitted to the Kappa test, in which the index was adjusted to > 0.8, representing the expression of RUNX-2 among the groups and in both periods; (C and D) Photomicrographs in a higher original objective (x100) about the 14 and 42 days of peri- implant bone healing from RLX group showing a moderate labeling for 14 days and middle labeling for 42 days of the biomarker RUNX-2 represented by red arrows
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