+ Pathophysiology of fasting In patients with severe insulin deficiency, a prolonged fast in the absence of adequate insulin can lead to excessive glycogen breakdown and increased gluconeogenesis and ketogenesis, leading to hyperglycaemia and ketoacidosis.
{"Image DocumentName": "Pathophysiology of fasting", "Image ImageDescription": "Oxidation of fatty acids generates ketones that can be used as fuel by skeletal and cardiac muscle, liver kidney and adipose tissue, sparing glucose for continued utilisation by brain and erythrocytes. In patients with diabetes mellitus, this glucose homeostasis is altered by the underlying condition and often by pharmacological agents designed to enhance or supplement insulin secretion. In patients with type 1 diabetes, glucagon secretion may fail to increase appropriately in response to hypoglycaemia.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}