Extrinsic Apoptosis Two major classes of caspases:
{"Image DocumentName": "Extrinsic Apoptosis Two major classes of caspases:", "Image ImageDescription": "Initiator caspases 8,9,10: initiates the onset of apoptosis by activating the executioner caspases. Executioner caspases 3,6,7: destroy actual targets in the cell to execute apoptosis. Caspases target: FAK (focal adhesion kinase): inactivation of FAK disrupt cell adhesion, leading to detachment of the apoptotic cell from its neighbors. Lamins: important component of the nuclear envelope, cleavage of lamins leads to disassembly of the nuclear lamina. Proteins required for cell structure: actin, intermediate filaments, etc--cleavage of these proteins lead to changes in cell shape and the surface blebbing. Endonuclease CAD: responsible for chromosome fragmentation. CAD cuts DNA into small fragments. CAD normally binds to an inhibitor protein. Caspases cleaves the inhibitor protein to activate CAD. Enzymes involved in DNA repair.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}