Teràpies anti IL-1 Neutrophils Osteoclasts Bone Cartilage Osteoblasts Chondrocytes Bone Synovial Space IL-6 PGE 2 IL-8 Synovial membrane Capsule Pannu
{"Image DocumentName": "Ter\u00e0pies anti IL-1 IL-1 B o n e C a r t i l a g e B o n e", "Image ImageDescription": "Synovial membrane. IL-8. C. a. r. t. i. l. a. g. e. PGE2. IL-6. N. e. u. t. r. o. p. h. i. l. s. IL-1. Capsule. Synovial. Space. Interleukin-1 (IL-1) is a pivotal cytokine involved in the pathophysiology of rheumatoid arthritis (RA).1. IL-1 is a proinflammatory cytokine that amplifies and perpetuates the disease process in RA.1. There are increased amounts of IL-1 in the synovium of patients with RA, particularly those patients with erosive disease.2,3. Early in the RA disease process, IL-1 acts synergistically with other cytokines to increase production of matrix metalloproteases, such as collagenase and stromelysin, by chondrocytes. These enzymes destroy components of the cartilage matrix.1. IL-1 also activates osteoclasts, the cells involved in bone resorption.4. IL-1 increases the expression of adhesion molecules on the endothelium, contributing to the migration of neutrophils and lymphocytes from the systemic circulation.1. In addition, IL-1 stimulates synovial fibroblasts to produce additional proinflammatory mediators, such as IL-8, prostaglandin-E2, and IL-6. These mediators are responsible for the acute and chronic inflammation characteristic of RA Dinarello CA. Biologic basis for interleukin-1 in disease. Blood. 1996;87: Eastgate JA, Symons JA, Wood NC, Grinlinton FM, di Giovine FS, Duff GW. Correlation of plasma interleukin-1 levels with disease activity in rheumatoid arthritis. Lancet. 1988;2: Fong K-Y, Boey W-H, Koh W-H, Feng P-H. Cytokine concentrations in the synovial fluid and plasma of rheumatoid arthritis patients: correlation with bony erosions. Clin Exp Biol. 1994;12: Gravallese EM, Goldring SR. Cellular mechanisms and the role of cytokines in bone erosions in rheumatoid arthritis. Arthritis Rheum. 2000;43: C. h. o. n. d. r. o. c. y. t. e. s. Pannus. Osteoblasts. Osteoclasts. B. o. n. e.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}