23 PEGPH20 May Address a Key Limitation of Chemotherapy Efficacy HA-rich halos found on many types of aggressive tumors (breast, prostate, pancreatic) PEGPH20 collapses HA dependent pericellular halos on tumor cells Modulates resistance to chemotherapy HA TUMOR CELL + Enzyme=Halo degraded Halo PEGPH20 TUMOR CELL
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