DPP: Benefit of Diet + Exercise or Metformin on Diabetes Prevention in At-risk Patients
{"Image DocumentName": "DPP: Benefit of Diet + Exercise or Metformin on Diabetes Prevention in At-risk Patients", "Image ImageDescription": "N = 3234 with IFG and IGT, without diabetes. 40. Placebo. P  30. Metformin. \uf0af31% < Cumulative. incidence of diabetes. (%) 20. Lifestyle. \uf0af58% < In DPP, 3234 nondiabetic persons with elevated fasting and post-load plasma glucose concentrations were randomly assigned to placebo, metformin (850 mg twice daily), or a lifestyle-modification program with the goals of at least a 7% weight loss and at least 150 minutes of physical activity per week. The mean age of the participants was 51 years, and the mean BMI was 34.0; average follow-up was 2.8 years. Compared to placebo, the lifestyle intervention reduced the incidence of diabetes by 58% (95% CI, 48 to 66%) and metformin reduced the incidence by 31% (95% CI, 17 to 43%); the lifestyle intervention was significantly more effective than metformin. Knowler WC, Barrett-Connor E, Fowler SE, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346: Years.  vs placebo. IFG = impaired fasting glucose. Diabetes Prevention Program (DPP) Research Group. N Engl J Med 2002;346:", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}