Methods Correction for known and unknown factors: ''REDUCED'' dataset generation – probabilistic estimation of expression residuals (PEER) framework Structure of gene expression variation among populations – V st : (V T - V S )/V T ; V S =(V 1 *n 1 +V 2 *n 2 )/(n 1 +n 2 ) – top 5% probes: GO term enrichments
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