 HCV is a major cause of liver disease – Leading indication for liver transplantation – Leading cause of hepatocellular carcinoma (HCC) (approx.50% of HCC incidence)  Over the next 40-50 years, a projected: – 1.76 million with untreated HCV infection will develop cirrhosis – 400,000 will develop HCC – 1 million will dies from HCV-related complications  Substantial HCV-related costs 1 – Exceeds $5 billion annually – 2010-2019 estimated costs total $54.2 billion 1 McGarry et al.
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