11 Frequency of Transfusion in Patients with SCD Cooperative Study of Sickle Cell Disease 1 –50% of all patients with SCD, 60% of patients with homozygous disease (SCD-SS) had received at least 1 transfusion at enrollment 2 –5.2% of SCD-SS were receiving chronic transfusion 2 Single-center, 20-year prospective study 3 –62% of SCD adult patients received blood transfusion; transfused patients received a mean of 10 units of RBC/year (= 2 g iron/year) Transcranial Doppler (TCD) studies 4,5 –An estimated 10% of SCD children will receive chronic transfusion for a pathologic TCD 1.
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