Model of the different phases of Pseudomonas aeruginosa infection. After an initial colonization phase, mostly dependent on cell-associated virulence factors, the infectious process evolves either to a chronic infection characterized by low production of extracellular virulence factors or to an acute infection characterized by high production of cell-to-cell signaling dependent virulence factors. During acute exacerbation of chronic infection, the production of cell-to-cell signaling dependent v
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