On the properties of CF 3 Fluorine = most electronegative element in the periodic table; CF 3 = similar electronegativity to Oxygen (3.5); CF 3 = 2 ½ the volume of a Me group; Introduction of F or CF 3 in a molecule substantially alters its properties: lipophilicity, metabolic stability, bioavailability; No known natural products (so far) that contain a CF 3 group; Nearly 20% drugs and 35% agrochemicals on market today contain one of more fluorine atoms.
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