Class I Benefit >>> Risk Procedure/ Treatment SHOULD be performed/ administered Class IIa Benefit >> Risk Additional studies with focused objectives needed IT IS REASONABLE to perform procedure/administer treatment Class IIb Benefit Risk Additional studies with broad objectives needed; Additional registry data would be helpful Procedure/Treatment MAY BE CONSIDERED Class III Risk Benefit No additional studies needed Procedure/Treatment should NOT be performed/administered SINCE IT IS NOT HELPFUL AND MAY BE HARMFUL Should Is recommended Is indicated Is useful/effective/ beneficial Is reasonable Can be useful/effective/ beneficial Is probably recommended or indicated May/might be considered May/might be reasonable Usefulness/ effectiveness is unknown/unclear/ uncertain or not well established Is not recommended Is not indicated Should not Is not useful/effective/ beneficial May be harmful Applying Classification of Recommendations
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