MAPK pathways Stimulus
{"Image DocumentName": "MAPK pathways Stimulus", "Image ImageDescription": "Proliferation, differentiation, development, survival. A-Raf, B-Raf, C-Raf. Growth factors, mitogens. ERK1/2. MEK1/2. AMLKs, TAK, ASK1. MKK3/6. P38 MAPKa/b. MEKK1,4 MLKs ASK1. MKK4/7. SAPK/ JNK1,2,3. Inflammation, apoptosis, proliferation, differentiation. Stress, inflammatory cytokines, growth factors. MAPKKK. MAPKK. Human cancers often arise due to mutations in cellular signaling pathways that coordinate and regulate cell proliferation and survival. The mitogen-activated protein kinase (MAPK) pathways are major signal transduction routes that transfer and amplify messages from the cell surface to the nucleus.1,2. There are several distinct MAPK pathways, important in the regulation of cell proliferation, differentiation, development, inflammation, survival and migration.1,2. References. 1. Kolch W. Biochem J 2000; 351: 289\u2013 Schaeffer HJ, Weber MJ. Mol Cell Biol 1999; 19: 2435\u20132444. MAPK. Biologic response. MAPK, mitogen-activated protein kinase; MEK, MAPK kinase; ERK, extracellular signal-regulated kinase.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}