BID PPI (56) 250 GERD patients Typical (135) QD PPI (79) Abnormal pH Monitoring in Symptomatic Patients Taking PPIs  pH testing should only be performed after patients have failed double-dose PPI, if testing on medication Extra-esophageal (115) BID PPI (75) QD PPI (40) 1.2 (0%-28%) 0.3 (0%-15%) 0 (0%-4.8%) 0.3 (0%-30%) % time pH <4 24 (31%) 4 (7%) 1 (1%) 12 (30%) # abnormal Charbel S, et al.
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