Major Bleeding Data Elements
{"Image DocumentName": "Major Bleeding Data Elements", "Image ImageDescription": "Definition. TIMI1. GUSTO2. CURE3. Trial. TRITON. CHARISMA. CURE. Major \u2013 fatal / life threatening or severe bleeding. Fatal / life threatening (related to instrumentation, spontaneous, trauma), ICH, Hb \u2193 \u22655 g/dL, or absolute. HCT \u2193 \u226515% Fatal, ICH, or causes haemodynamic compromise and requires intervention. Fatal / Life threatening. Fatal, ICH, requires surgery, hypotension requiring inotropes, Hb \u2193 \u22655 g/dL, or transfusion \u22654 U. Other major. Disabling, intraocular. with vision loss, or transfusion 2-3 U. PLATO4. PLATO. Fatal / Life threatening. Fatal, ICH, intrapericardial with tamponade, hypovolaemic shock / hypotension requiring pressors or surgery, Hb \u2193 >5 g/dL, or transfusion \u22654 U. Other major. Disabling (intraocular with permanent vision loss), Hb \u2193 3-5 g/dL, or transfusion 2-3 U. Listed here are the data elements of the various bleeding definitions used in the antiplatelet therapy trials. Because of the difficulties in comparing these different definitions we can compare similar data elements across trials, or compare definitions that are reconstructed post-hoc (like TIMI major for example). ICH = intracranial haemorrhage; PLATO = Platelet Inhibition and Patient Outcomes. Chesebro, JH et al. Circulation GUSTO Investigators. NEJM Yusuf S, et al. N Engl J Med. 2001;345: Cannon CP, et al. J Am Coll Cardiol. 2007;50:", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}