DIURETIC EFFECTS Volume and preload No direct effect on CO, but
{"Image DocumentName": "DIURETIC EFFECTS Volume and preload No direct effect on CO, but", "Image ImageDescription": "Improve symptoms of congestion. No direct effect on CO, but. excessive preload reduction may. Improves arterial distensibility. Neurohormonal activation. Levels of NA, Ang II. Exception: with spironolactone. Treatment of heart failure. Diuretics: Mechanisms of action. Diuretics decrease volume and preload, and as a result are very effective at improving the signs of pulmonary and systemic venous congestion. They do not change the cardiac output (CO), but CO may fall if an excessive decrease in preload occurs. They slightly improve arterial distensibility, but this effect is of no clinical relevance. The main drawback to diuretics use is their effect on the neurohormonal milieu, increasing the plasma levels of noradrenaline (NA), angiotensin II (Ang II) and aldosterone, and the plasma renin activity (PRA).", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}