Itraconazole 3A4 Interactions Affecting Pharmacokinetics of Other Drugs
{"Image DocumentName": "Itraconazole 3A4 Interactions Affecting Pharmacokinetics of Other Drugs", "Image ImageDescription": "Effect. Alternatives/Management. HMG-CoA reductase. (lovastatin, simvastatin, atorvastatin) 3-20 fold \uf0e9 Cmax, AUC0-24, t1/2. Fluvastatin, pravastatin, rosuvastin. Benzodiazepines. (midazolam, triazolam, diazepam) \uf0e9Cmax, AUC, t1/2, F, \uf0ea clearance. Oxazepam, estolazam, temazepam. Anxiolytics, sedatives. (buspirone) 13-fold \uf0e9 Cmax, AUC0-24. Zolpidem. Antipsychotics. (Haloperidol) \uf0e9 30% AUC. Clozapine. Immunosuppressants. CsA. Tacrolimus. \uf0e9 Cmin >50% \uf0e9 Cmin 5-fold. Empirically reduce dosage by 50% and monitor levels. Corticosteroids. Methylprednisolone, dexamethazone. Prednisolone. \uf0e9 3-4x increase in AUC. \uf0e9 15-30% increase in t1/2. Adrenal-suppressant effects. Calcium channel blockers. Felodipine. \uf0e9 6-8x fold increase in AUC. Avoid. Chemotherapy. (Cyclophosphamide, busulfan, vinca alkaloids) \uf0e9 Css > 25-50% Avoid concomitant use, especially for conditioning therapy.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}