ATP Ras-Raf-MAPK Proliferation Pi3K-AKT Survival Ligand Extracellular domain Trans-membrane domain Tyrosine kinase domain Tyrosine phosphorylation EGFR internalisation Degradation / recycling EGFR signals for longer at the cell membrane Wild-type EGFRMutant EGFR EGFR mutation causes conformational change and increased activation Arteaga 2006; Gadzar et al 2004; Hendricks et al 2006; Sordella et al 2004
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