Figure 1 Integration of immunoediting and oncogenesis during cancer progression. Oncogenesis initiates the formation of
{"Image DocumentName": "Figure 1 Integration of immunoediting and oncogenesis during cancer progression. Oncogenesis initiates the formation of", "Image ImageDescription": "transformed cells that are attacked by immune cells as the result of neoantigen presentation. This process of immune surveillance. imposes a selection for transformed cells that acquire tactics to escape control. Genetic instability driven by oncogenesis facilitates. evolution of strategies for immune evasion or suppression, the latter of which may help tilt the tumor microenvironment from hostile to. supportive for tumor cells. As the battle evolves between tumor cells and the immune system, representing the process of. immunoediting, a state of immune equilibrium may be achieved that corresponds to a dynamic but dormant disease that is clinically. occult. Further iteration of evasion mechanisms to defeat different elements of the immune system may ultimately drive immune. suppression beyond the local microenvironment, achieving immune escape and thereby licensing invasive and metastatic behaviors that. define progressive disease. Invasion and metastasis may be derivative of immune escape since the former are presumably impotent. while immune surveillance prevails beyond the local microenviroment. While mutations may initiate cancer, modifiers and. microenvironmental factors including those sculpted by the process of immunoediting may dictate the course of disease. Prendergast, Oncogene", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}