Precision in timing of Pcell firing: EPSP – IPSP sequence Voltage clamp Current clamp Afferent EPSC sum 2 ms Di-synaptic IPSC EPSP Di-synaptic EPSP Inhibition functional…blocked Two puise – Inhibition functional - Inhibition blocked 2.5 ms5 ms 10 ms Precise spike timing depends on a biphasic EPSP – IPSP sequence Pouille & Scanziani, Science, 2001
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