Two examples of cis and trans acting effects of CNVs on gene expressions. Left: Two modules are associated with putative regulators and external segment CNVs. The upper half of the heatmap shows the CNV of segment 9 (chr3p 13-14.2), the expression of MITF (chr3p 14.1) and associated genes on other chromosomes. The module is expressed in melanoma cell lines (ME). The lower half of the heatmap shows the CNV of segment 17 (chr6q 21-27), the expressions of MYB (chr6q 22) and associated genes on other chromosomes. The module is expressed in leukemia cell lines (LE). Right: mRNA expressions of the MYB module under unperturbed and radiation conditions. The upper half of the heatmap shows the CNV of segment 17, expressions of MYB and associated genes under the unperturbed condition. The lower half of the heatmap shows the expressions of MYB and associated genes under radiation.
{}