Mannitol Buys time Osmotic gradient between plasma /brain 1g/Kg (5ml/Kg) 0.5g/100mls of 20% over 15mins 50ml aliquots of 20% over 10 mins Equilibration, fully osmolised at 310 mOSM, don't give if >320 May cause ATN, Hypertension & high intracellular osmotic pressure, phlebitis
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