Possible course of renal involvement in type 2 DM progressors non progressors 5 10 15 20 25 30 160 120 80 40 0 5 10 15 20 25 30 2000 200 20 2 Diabetes duration (years) AER ( g/min) GFR (ml/min 1.73m 2 ) Incipient nephropathy Overt nephropathy 2 ml/min/year 4-7 ml/min/year Mogensen et al., 83, 86, 89, 90 ESRF ~20%
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