Proliferation Granulation tissue Epithelial cells Endothelial cells
{"Image DocumentName": "Proliferation Granulation tissue Epithelial cells Endothelial cells", "Image ImageDescription": "Migrate to the sides of edges. Endothelial cells. Angiogenesis. Fibroblasts. ECM formation. Granulation. tissue. Granulation tissue starts to invade the wound around 4 days. Macrophages and fibroblasts are the major cells involved. Macrophages provide the growth factors necessary to stimulate fibroplasia and angiogenesis. Fibroblasts produce ECM. PDGF and TGF stim fibrobalsts. Eventually the ECM is replaced by a collageous matrix. Once this occurs the scar becomes acellular. Dysregulation in this process leads to keloid scars, morphea and scleroderma. Neovascularization is stim by bFGF< VEGF, in the first 3 days from the injury. bFGF stim endothelial cells to produce plasminogen activator and procollagenase>>>collagenase, breakdown of the BMs., allowing the blood vessel formaiton.Apoptosis is regalated by thrombospondins1, 2 angiostatin and angiopoietin2.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}