Proposed algorithm for patients with loss of response to infliximab Positive HACA Change to another anti-TNF agent Change to non– anti-TNF agent persistent disease Increase infliximab dose or frequency Change to non– anti-TNF agent Change to different anti-TNF agent Change to different anti-TNF agent Subtherapeutic IFX concentration Therapeutic IFX concentration Active disease on endoscopy/radiology.
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