CM-10 Dose of ACE Inhibitor Achieved in CHARM Added Compared to Randomized Outcome Trials Using Forced Titration Trial ACE-inhibitor (% in CHARM Added) Mean dose in outcome trial (mg) Mean dose in CHARM-Added (mg) SOLVDEnalapril (27%) ATLASLisinopril (19%)3.2 † 22.5 † 17.7 GISSI 3LisinoprilN/A17.7 SAVECaptopril (17%) AIRERamipril (11%) TRACETrandolapril (6%) † US and European guidelines recommend target dose of 20 mg/d.
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