Orion Corporation Aspects of the improved model: Distribution of random effects, estimation method, implementing weight as a covariate $SUBROUTINES ADVAN2;This is a predefined subroutine for 1-compartment model ;with first order absorption $PK D1=THETA(6)*EXP(ETA(3)) ;log-normal distribution KA=THETA(1)*EXP(ETA(1));log-normal distribution V=THETA(2)*EXP(ETA(2)*THETA(5)) *WT/70;log-normal distribution, linear scaling by weight CL=THETA(3)*EXP(ETA(2)) *WT/70;log-normal distribution, linear scaling by weight K=CL/V S2=V $ERROR IPRED=F IRES=DV-IPRED W=THETA(4) ;add error W2=THETA(7) ;add err postabs IWRES=IRES/W IF(TIME.GT.2) IWRES=IRES/W2 Y=IPRED+W*EPS(1) IF(TIME.GT.2) Y=IPRED+W2*EPS(1) $THETA (.1,2) (0,33) (0,3) (0,1) (0,.5) (0,.3) (0,.3) $OMEGA.2.2.2 $SIGMA 1 FIX $EST METHOD=1 INTER MAXEVAL=9999 PRINT=5;method is First Order Conditional Estimation with $COV;Interaction 1.1.200715 Pyry Välitalo SSL Presentation
{}