Approaches to a better surrogate
{"Image DocumentName": "Approaches to a better surrogate", "Image ImageDescription": "Week 16 vs. Week 24 for HIV RNA. Week 24 will likely be a better predictor of clinical outcome than Week 16. FDA usually ask for Week 24 results in accelerated approval of HIV drugs. Data beyond Week 24 are also requested and reviewed. Based on the predicted value of the surrogate, compute what kind of efficacy we will need to reliably predict a significant and meaningful clinical outcome at the end for traditional approval.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}