Lung Cancer: What is it Uncontrolled growth of malignant cells in one or both lungs and tracheo-bronchial tree.
{"Image DocumentName": "Lung Cancer: What is it?Uncontrolled growth of malignant cells in one or both lungs and tracheo-bronchial tree.", "Image ImageDescription": "Arises from protective or ciliated cells in the bronchial epithelium. Begins as a result of repeated carcinogenic irritation causing increased rates of cell replication. Proliferation of abnormal cells leads to hyperplasia, dysplasia or carcinoma in situ. Lung cancer is thought to arise from a single stem cell that is capable of expressing a variety of phenotypes. Normally, this stem cell differentiates to form those cells found in the tracheobronchial tree, including pseudostratified reserved cells, ciliated goblet columnar cells, neuroendocrine cells, and type I and II pneumocytes. However, as with any cell capable of division, hyperplastic, metaplastic, or neoplastic changes are possible. These may be caused by repeated exposure to a carcinogen, such as tobacco smoke, leading to an increased rate of cell replication and uncontrolled growth of malignant cells. There is strong evidence for a genetic predisposition to lung cancer as various chromosomal abnormalities have been demonstrated. In almost all cases of primary lung cancer as well as metastatic tumors, lesions occur in chromosome region 3p (14-23). Another abnormality is the mutation of the p53 gene. These and numerous other rearrangement and deletion types of chromosomal abnormalities are thought to result from the effects of carcinogens or the genetic instability observed in malignant transformation. Ginsberg RJ, Vokes EE, Rosenzweig K. Non-small cell lung cancer. In: DeVita VT Jr , Hellman S, Rosenberg SA, eds. Cancer Principles and Practice of Oncology. 6th ed. Philadelphia, Pa: Lippincott-Raven; 2001: Feld R, Ginsberg RJ, Payne DG, Shepherd FA. Lung. In: Abeloff MD, Armitage JO, Lichter AS, Niederhuber JE, eds. Clinical Oncology. 2nd ed. New York, NY: Churchill Livingstone; 2000:", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}